Abstract 2528: Age and body mass index are predictive of cancer diagnosis among women with BIRADS 4 mammograms.

Background: Women with BIRADS 4 mammograms are referred for biopsy and have a 15-30% one year risk of breast cancer. Identifying pre-test predictors of cancer among women with BIRADS 4 mammograms may be useful in reducing false-positives. Methods: Women with BIRADS 4 mammograms were recruited from the University of Pennsylvania Health System from 2009-2012. Women Results: Among 269 participants with BIRADS 4 mammogram, 41 (15%) were diagnosed with cancer (DCIS N=16, Invasive N=25). Women diagnosed with cancer were significantly older than women with benign findings (p 2 had three times the odds of cancer diagnosis compared to women with BMI 2 (OR=3.33, 95% CI 1.18-4.34, p=0.02). Family history (OR=1.42, 95% CI 0.64-3.16, p=0.39) and HRT (OR=1.44, 95% CI 0.60-3.42, 0.41) were associated with elevated odds of cancer, but were not statistically significant. Conclusions: Age and BMI were predictors of cancer diagnosis among women with BIRADS 4 mammograms. Recruitment for this cohort is ongoing, and analysis is currently being expanded to include breast cancer associated SNPs, area-based and volumetric measures of breast density, and novel measures of breast complexity. Citation Format: Anne Marie McCarthy, Susan M. Domchek, Despina Kontos, Emily F. Conant, Mirar Bristol Demeter, Marisa Jones, Leigh Boghossian, Erin McGuire, Katrina Armstrong. Age and body mass index are predictive of cancer diagnosis among women with BIRADS 4 mammograms. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2528. doi:10.1158/1538-7445.AM2013-2528