Comparative study between Magnesium valprote sustained release tablets with Sertraline in the treatment of refractory depression

Objective:To compare the efficacy and safety of magnesium valprote sustained release tablets and sertraline in treating refractory depression.Methods:50 patients with refracttory depression were divided into magnesium valprote sustained release tablets group(n=30) and sertraline group(n=20) with basic treatment of sertraline and followed for 8 weeks.Hamilton Depressive Scale(HAMD-17)and Treatment Emergent Symptom Scale(TESS) were used to evaluatethe efficacy and side effects at the point of week 1,weeks 2,weeks 4 and week 8.Results:After 8 weeks treatment,the total score of HAMD and the score ofeach factor reduced significantly in magnesium valprote sustained release tablets group,and the scores of trea-tment factors was significantly lower in magnesium valprote sustained release tablets group than those in sertraline group,side effects were fewer and milder.Conclusion:Magnesium valprote sustained release tablets with sertraline are an effective and safe drug in treating refractory depression.