O6-methylguanine DNA Damage Signals Through Nfkb1/p50 to Potentiate DNA Strand Break-induced Cytotoxicity

and 6 hr of NFK-b, Nrf2 and TGF-b. MnSOD tet/tet cells, maintained in DOX, did show at 6 hr after irradiation a 50% increase in expression of Nrf2. Conclusions: MnSOD tet/tet cell lines are radiosensitive, as reflected in decreased irradiation induced gene expression which is only partially reversed by DOX. These novel mice and derived cell lines should prove valuable for understanding the link between antioxidant levels and irradiation responsive genes mediating both acute and chronic normal tissue damage effects. Acknowledgements: This project was supported by NIAID U191A168021. Author Disclosure: R. Kalash: None. J.R. Chaillet: None. F. Houghton: None. X. Zhang: None. M. Epperly: None. S. Cao: None. J.S. Greenberger: None.