Synthesis and Hybridization Properties of Amide‐Linked Thymidine Dimers Incorporated into Oligodeoxynucleotides.

Abstract Thymidine dimers, connected by amide or N-methyl amide linkages, have been prepared. The dimers have each been incorporated three times into normal strands of DNA by solid phase synthesis. Thermal denaturation studies indicated that these modifications caused little or no destabilization of the DNA:RNA duplex.