Amide imidazole derivative and application thereof

The invention belongs to the technical field of medicines, and relates to an amide imidazole derivative of the formula I as shown in the specification, a stereisomer and pharmaceutically acceptable salts, hydrate, solvate or prodrug of the amide imidazole derivative. In the formula, the substituent groups R, R1, Ar, M and X are defined as shown in the specification. The invention further relates to a method for preparing the compound of the formula I, a medicinal composition containing the compound, and application of the compound and the medicinal composition in preparing medicines for treating and/or preventing cancer and other skin proliferation diseases.