Risk Assessment During Longitudinal Progression of Cognition in Older Adults: A Community-based Bayesian Networks Model.

Background Cognitive dysfunction, particularly in Alzheimer's disease (AD), serious- ly affects the health and quality of life of older adults. Early detection can prevent and slow cogni- tive decline. Objective This study aimed at evaluating the role of socio-demographic variables, lifestyle, and physical characteristics in cognitive decline during AD progression and analyzing the probable causes and predicting stages of the disease. Methods By analyzing data of 301 subjects comprising normal elderly and patients with mild cog- nitive impairment (MCI) or AD from six communities in Taiyuan, China, we identified the influ- encing factors during AD progression by a logistic regression model (LR) and then assessed the as- sociations between variables and cognition using a Bayesian Networks (BNs) model. Results The LR revealed that age, sex, family status, education, income, character, depression, hy- pertension, disease history, physical exercise, reading, drinking, and job status were significantly associated with cognitive decline. The BNs model revealed that hypertension, education, job status, and depression affected cognitive status directly, while character, exercise, sex, reading, income, and family status had intermediate effects. Furthermore, we predicted probable cognitive stages of AD and analyzed probable causes of these stages using a model of causal and diagnostic reasoning. Conclusion The BNs model lays the foundation for causal analysis and causal inference of cogni- tive dysfunction, and the prediction model of cognition in older adults may help the development of strategies to control modifiable risk factors for early intervention in AD.Recent Advances in Anti-Infective Drug Discovery.