Effect of postdilatation following balloon expandable transcatheter aortic valve implantation

BACKGROUND: Postdilatation after transcatheter heart valve (THV) implantation was associated with larger aortic valve areas in large-scale registries; however, the specific effects of postdilatation are poorly understood. METHODS AND RESULTS: Among a total of 224 consecutive patients who underwent transcatheter aortic valve replacement using SAPIEN 3, 121 patients (54.0%) underwent postdilatation (same contrast volume: N = 101, +1 ml: N = 17, +2 ml: N = 3). THV diameter was assessed (a) during, (b) after implantation, (c) during postdilatation, and (d) after postdilatation by quantitative fluoroscopy. In the overall patients (N = 224), acute recoil was observed from during implantation (23.0 +/- 2.0 mm) to after implantation (22.5 +/- 2.0 mm, p < .001) with an absolute recoil of 0.52 +/- 0.25 mm. After postdilatation (N = 121), THV diameter significantly increased from 22.5 +/- 2.0 mm to 22.9 +/- 2.1 mm (p < .001), with smaller absolute recoil (0.39 +/- 0.21 mm, p < .001). Compared with those who did not undergo postdilatation, patients who underwent postdilatation had larger postprocedural THV area assessed by multi-slice computed tomography (471.4 +/- 78.1 mm(2) vs. 447.5 +/- 76.3 mm(2) , p = .02) and larger effective orifice area (EOA) assessed by echocardiography throughout 1 year (at 30 day, 1.66 +/- 0.33 cm(2) vs. 1.45 +/- 0.27 cm(2) , p < .001; at 6 month, 1.66 +/- 0.33 cm(2) vs. 1.44 +/- 0.29 cm(2) , p < .001; at 1 year, 1.69 +/- 0.38 cm(2) vs. 1.47 +/- 0.30 cm(2) , p < .001). CONCLUSIONS: Postdilatation after implantation of the SAPIEN 3 valve produced a larger THV diameter with less acute recoil, followed by larger EOA throughout 1 year. Further studies are needed to evaluate the impact of postdilatation on long-term clinical outcomes.