AMINOMETHYLATION OF PHOSPHINES BY ALKOXYMETHYLAMINES AND DIAMINOMETHANES

1. Methods for the aminomethylation of phosphines with alkoxymethylamines and diaminomethanes were developed. 2. Aminomethyl derivatives of asymmetric phosphines and optically active C-chiral and diastereomeric C- and P-chiral aminomethylphosphines were prepared. 3. An enatiomerically enriched (−)-dimethylaminomethyl-tert-butylphenylphosphine, with an asymmetric center at the P atom was synthesized.