Synthesis of (+)-HanagokenolA, (+)-Fortunins E, G, H, and (-)-SugikurojinA from Abietic Acid

A series of 12-hydroxy-substituted abietane diterpenes, functionalized on C19 or C 18, have been synthesized starting from 18-hydroxyferruginol. The first synthesis of antibacterial hanagokenol A and fortunins E, G, and H, and a new procedure for preparing sugikurojin A and the immunosuppressive 19-hydroxyferruginol are reported.