Binding Characteristics of the Antiendotoxin Antibody Xomen-E5 to Bacterial Whole-Cell Antigens

Sepsis is a common, life-threatening complication of infection with gram-negative bacteria. While the pathophysiology of gram-negative sepsis has not been fully elucidated, a significant portion of the clinical syndrome can probably be attributed to the activation by endotoxin of a cascade of secondary mediators. These mediators initiate a series of complicated events, including systemic response to infection (fever or hypothermia, tachycardia, tachypnea) and dysfunction or failure of critical organ systems including the kidney, lung, brain, liver, and cardiovascular and coagulation systems [1].