Human exposure to trichloroethylene is associated with increased variability of blood DNA methylation that is enriched in genes and pathways related to autoimmune disease and cancer

Rachael V. Phillips,Linda Rieswijk,Alan Hubbard,Roel Vermeulen,Jinming Zhang,Wei Hu,Laiyu Li,Bryan A. Bassig,Jason Y.Y. Wong,Boris Reiss,Yongshun Huang,Cuiju Wen,Mark P. Purdue,Xiaojiang Tang,Luoping Zhang,Martyn T. Smith,Nathaniel Rothman,Qing Lan

Human exposure to trichloroethylene is associated with increased variability of blood DNA methylation that is enriched in genes and pathways related to autoimmune disease and cancer

2019

Rachael V. Phillips
Linda Rieswijk
Alan Hubbard
Roel Vermeulen
Jinming Zhang
Wei Hu
Laiyu Li
Bryan A. Bassig
Jason Y.Y. Wong
Boris Reiss
Yongshun Huang
Cuiju Wen
Mark P. Purdue
Xiaojiang Tang
Luoping Zhang
Martyn T. Smith
Nathaniel Rothman
Qing Lan

ABSTRACTHuman exposure to trichloroethylene (TCE) is linked to kidney cancer, autoimmune diseases, and probably non-Hodgkin lymphoma. Additionally, TCE exposed mice and cell cultures show altered D...

Keywords:

Genetics
Gene
Autoimmune disease
DNA methylation
Biology
Cancer
Trichloroethylene
Cancer research
Molecular biology
Cell culture
Epigenetics
Kidney cancer
Lymphoma

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