РАЗРАБОТКА СОСТАВА И ТЕХНОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ СУСПЕНЗИИ ПИРОКСИКАМА

The paper deals with the issue of creating a suspension of piroxicam and selection of a composition of excipients – stabilizer and prolongator providing optimum rheology control and allowing a constant rate of release from the dosage form of piroxicam. Studies on the optimal composition of the stabilizer and prolongator included biopharmaceutical studies in vitro performed by analysing of the release of piroxicam from the respective samples through a semipermeable membrane into the buffer solution. Quantitative determination of piroxicam was performed spectrophotometrically. Based on the data obtained, following compositions were selected for further studies, including pharmacological: 1) Piroxicam 0,5 %, methylcellulose 0,25 %, Gum 0,2 %; 2) 0,5 % piroxicam, 0,25 % lecithin, 0,4 % plasdon; 3) 0,5 % piroxicam, 0,25 % lecithin, 0,4 % Caledon. Thus, for the fi rst time a novel dosage form (suspension) was proposed for the well-known generic piroxicam. Optimal compositions containing stabilizers and prolongators were determined.