TOXICITY STUDY OF THE AQUEOUS EXTRACT OF TEUCRIUM CAPITATUM L AND SILENE VULGARIS OF THE EL HAJEB REGION (CENTRAL MOROCCO)

In this study, we studied the acute toxicity of the aqueous extract of two plants Teucrium capitatum L and Silene vulgaris, selected from an ethnobotanical study of the EL HAJEB region (Morocco), followed by a phytochemical, antimycobacterial and toxicity study. Administration of the aqueous extract at different doses taken orally on male and female mice to severe symptoms of toxicity. These symptoms are caused by respiratory problems, tremors, paralysis of the hind legs and comas causing death. According to the results obtained, the highest dose killing all animals or 100% lethal dose (LD100) is 9600 mg / kg / vo for Teucrium capitatum L and 4800 mg / kg / vo for Silene vulgaris. Whereas for the maximum tolerated dose (DMT) it is 1200mg / kg / vo for Teucrium capitatum L and 600mg / kg / vo for Silene vulgars. . The LD50 value (5880 mg / kg /…