Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

Sara N. Andres,C. Denise Appel,James W. Westmoreland,Jessica S. Williams,Yvonne Nguyen,Patrick D Robertson,Michael A. Resnick,R. Scott Williams

Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair

2015

Sara N. Andres
C. Denise Appel
James W. Westmoreland
Jessica S. Williams
Yvonne Nguyen
Patrick D Robertson
Michael A. Resnick
R. Scott Williams

Structural, biophysical and genetic analyses reveal that Schizosaccharomyces pombe Ctp1 forms a flexible tetramer with multivalent DNA-binding and bridging activities that contribute to Ctp1's role in repair of DNA double-strand breaks.

Keywords:

DNA clamp
Base pair
DNA ligase
DNA supercoil
Replication protein A
Biology
Double Strand Break Repair
Nucleotide excision repair
DNA polymerase II
Molecular biology

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