Response to Letter Regarding Article, “Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarction”

Dr Januzzi raises several interesting points regarding galectin-3 levels after acute myocardial infarction. We found that galectin-3 increased modestly but significantly (by ≈12%) between baseline (≈day 2) and 24 weeks.1 Serial measurement of galectin-3 in healthy volunteers suggests a reference change value of the order of 61% for galectin-3.2 A recent analysis of serial galectin-3 levels in 2 chronic heart failure trials suggests, however, that a rise …