EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

Dejiu Zhang,Kaige Yan,Guangqiao Liu,Guangtao Song,Jiejian Luo,Yi Shi,Erchao Cheng,Shan Wu,Taijiao Jiang,Jizhong Lou,Ning Gao,Yan Qin

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

2016

Dejiu Zhang
Kaige Yan
Guangqiao Liu
Guangtao Song
Jiejian Luo
Yi Shi
Erchao Cheng
Shan Wu
Taijiao Jiang
Jizhong Lou
Ning Gao
Yan Qin

Cryo-EM structures of EF4 with the 70S ribosome, in conjunction with functional assays, reveal insights into the mechanism of EF4-mediated tRNA back-translocation.

Keywords:

RNA transport
Escherichia coli
Molecular biology
Translation (biology)
Chromosomal translocation
Ribosome
Biochemistry
Transfer RNA
Escherichia coli Proteins
T arm
Biology
Peptidyl transferase
A-site
Mutagenesis

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