TRIAMMINEPLATINUM(II) COORDINATED TO A GUANINE DOES NOT PREVENT PLATINATION OF AN ADJACENT GUANINE IN SINGLE-STRANDED OLIGONUCLEOTIDES

Adjacent guanines within single-stranded oligodeoxyribonucleotides are shown to bind easily two dicationic platinum centers. This type of cumulative binding, which is favored by high ionic strength, should be taken into account in kinetic studies of metal−DNA interactions, especially when the metal complex is in excess.