Diagnostic value of bladder tumor fibronectin in patients with bladder tumor: A systematic review with meta-analysis

Abstract Objectives Bladder tumor fibronectin (BTF) has been related as a promising biomarker for the early diagnosis of bladder tumor. The meta-analysis was used to establish the diagnostic value of bladder tumor fibronectin in diagnosing bladder tumor. Methods Relevant literatures evaluating the value of BTF in the diagnosis of bladder tumor were searched in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Data. Summary estimates were used to evaluate the value of BTF in the diagnosis of bladder tumor by using the Meta-DiSc and STATA 11.0 statistical software. Results The meta-analysis included 5 studies (649 patients, 291 controls). The summary estimates revealed that the pooled sensitivity was 81% (95% confidence interval [CI]: 74%–85.1%) and specificity was 80% (95%CI 74%–84%). In addition, the area under the summary ROC curve (AUC) was 0.86 (95%CI 0.82–0.89). Conclusion BTF is a potential marker for the diagnosis of bladder tumor, and more prospective studies are needed in the future.