Effect of tranexamic acid in perioperative blood loss associated with total knee replacement: A KIMS experience

Materials and methods: A retrospective and prospective study was carried out on 148 patients undergoing total knee replacement. 88 patients received tranexamic acid (10 mg/kg, iv) just before the cementation, 3 hours and 6 hours post operatively. 60 patients did not receive tranexamic acid. Perioperative blood loss was measured by the amount of post-operative drain, and drop in hemoglobin levels. The number of patients who needed blood transfusion and the number of units transfused was recorded and possible postoperative thromboembolic complications were studied clinically.