On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis

For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commerically available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive glucose, sensor, we obtained a device was tested in healthy volunteers during a 75-g oral glucose tolerance test and in Type 2 (non-insulin-dependent) diabetic patients