Pharmacological targeting of the b-amyloid precursor protein intracellular

Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing withtranscriptionalmodulationactivity,whoseoverexpressioncausesvariousAlzheimer’sdisease(AD)-relateddysfunctions. Here we report that 1-(39,49-dichloro-2-fluoro[1,19-biphenyl]-4-yl)-cyclopropanecarboxylicacid) (CHF5074), a compound that favorably affects neurodegeneration, neuroinflammation and memorydeficit in transgenic mouse models of AD, interacts with the AICD and impairs its nuclear activity. Inneuroglioma-APPswecells,CHF5074shiftedAPPcleavagefromAb