Glycopeptide derivative and its pharmaceutically acceptable salts, and their preparation method and application

The invention discloses a glycopeptide derivative as shown in general formula (I), which is shown in the description, and its pharmaceutically acceptable salts, wherein R1 is H, 2-alkylamine-ethyl, substituted benzyl, substituted hydrocinnamoyl, or linear acyl containing carbon-carbon bonds, and a benzene ring on the benzyl or hydrocinnamoyl has halogen, hydroxy, amino, dimethylamino, and trifluoromethyl, or has a benzene ring substituted by halogen, hydroxy or trifluoromethyl; the linear acyl contains 1 to 6 carbon-carbon double bonds; R2 is OH or C1-C5 linear amino, the terminal of the C1-C5linear amino may be provided with dimethylamino or substituted benzyl, and the benzene ring of the substituted benzyl is provided with halogen, cyano group or nitro. The compound provided herein hasgood antibacterial activity, provides enhanced antibacterial property for glycopeptide antibiotic resistance bacteria, and is significant to the development of novel antibacterial drugs.