Association between H19 polymorphisms and NSCLC risk in a Chinese Population.

PURPOSE: Long non-coding RNAs (lncRNA) polymorphisms have been reported to associate with the carcinogenicity mechanisms. The association between lncRNA H19 polymorphisms and the risk of non-small cell lung cancer (NSCLC) in Chinese population has not been reported yet. We designed this case-control study to evaluate the effects of H19 polymorphisms on NSCLC susceptibility. METHODS: In this case-control study, four single nucleotide polymorphisms (SNPs) (rs2067051, rs217727, rs2839698 and rs4929984) in H19 gene were genotyped in a Chinese population which consisted of 564 NSCLC cases and 1536 controls. RESULTS: rs2067051 was associated with a significantly decreased risk of NSCLC in our population [AA vs. GG: adjusted odds ratio (OR) = 0.75, 95% confidence interval (CI)=0.60-0.93; Additive model: OR=0.79, 95%CI=0.67-0.93)]. rs217727 was related to significantly increased NSCLC susceptibility (TT vs. CC: OR=1.16, 95%CI=1.01-1.33; Additive model: OR=1.16, 95%CI=1.01-1.33). However, no significant association was observed between rs2839698, rs4929984 and NSCLC risk. CONCLUSIONS: H19 polymorphism rs2067051 and rs217727 might influence NSCLC susceptibility and the mechanism warrants further exploration.