A double-stranded oligonucleotide comprising Amphiregulin specific sequence and a composition for treating and preventing fibrosis related diseases and respiratory related diseases

The present invention provides a double-stranded oligonucleotide that is highly specific and can efficiently inhibit the expression of MPPregulin, preferably a double-stranded oligonucleotide comprising a sequence of RNA / RNA, DNA / DNA, or DNA / RNA hybrid form, The present invention relates to a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide and to nanoparticles comprising the double-stranded oligonucleotide structure and its use for the prevention or treatment of fibrosis or respiratory diseases.