LEVELS OF CA125 MARKER IN PATIENTS WITH DIFFERENT HISTOLOGIC TYPES OF OVARIAN CANCER

Ovarian cancer is one of the most lethal cancers among women worldwide. The most used tumor marker in ovarian cancer is CA 125, elevated levels of CA 125 having been recorded in 80% of patients with advanced stages of the disease. The objective of the present study was to evaluate and compare CA 125 levels in relation with different histologic types of ovarian cancer. We analyzed 124 women diagnosed with ovarian cancer between 2010 and 2016. Four parameters were investigated: age at diagnosis, level of CA 125 at diagnosis, histologic type and location of the tumor. The results show a mean age at diagnosis of 50.29 ± 9.83 years. The serous ovarian cancer was the most frequent histologic type (45.97%). Highest mean levels of CA 125 were recorded in endometrioid (335 U/ml) and serous (792,48 U/ml) tumors. Lower levels were registered in clear cell (139,9 U/ml) and mucinous (169,49 U/ml) tumors.