Glucosyl and galactosyl transferase activities of diabetic (db/db) and obese (ob/ob) mice kidneys

Abstract 1. 1. Glucosyl and galactosyl activities were determined in kidney cortex tissue prepared from two strains of mice, genetically diabetic and obese mice. 2. 2. These activities were measured as a function of ageing between 6 weeks and 13 months. 3. 3. For both strains glucosyl transferase activity was shown to increase with respect to ageing whereas galactosyl transferase activity decreased at the same time. 4. 4. These changes of enzymatic activities would suggest that a smaller increase of hydroxylysine-linked glycans than expected was observed under these pathological conditions.