Preparation and Evaluation of Proniosomal Gel of Neem Seed Oil

Niosomes are non-ionic surfactant vesicles which act as drug carrier systems. In the present study, we carried preparation and evaluation of proniosomal gel of neem seed oil. The proniosomal gel was prepared using span 40, soya lecithin and cholesterol, using neem seed oil as the active pharmaceutical ingredient. Alcohol and phosphate buffer pH 7.4 were used in formulation as pharmaceutical excipients. The resulting formulations were evaluated and observed by transmission electron microscopy. Evaluation of formulation yielded optimum results like uniform size distribution 75-80% drug entrapment and microbiological data. It is concluded that it is viable to prepare an acceptable pronisomal gel of neem seed oil for therapeutic applications.