The influence of intravenous ozone therapy on the electrophysiological properties of myocardium during combined treatment of the patients presenting with arterial hypertension

The present investigation included 65 patients (36 men and 29 women of the mean age of 51.3±6.7 years) presenting with grade I-II arterial hypertension (AH) and undergoing intravenous ozone therapy in combination with the intake of antihypertensive preparations. ECG studies showed that a course of ozone therapy decreases the degree of in homogeneity of intra-myocardial electrophysiological processes in the patients with AH as apparent from reduced dispersion of P-wave and corrected QT-interval. Analysis of the results of high-resolution ECG revealed a significant decrease in the frequency of ventricular late potentials from 29.2% (19 patients) to 13.8% (9 patients) (χ2=4.5; p=0.03) whereas the decrease in the frequency of atrial late potentials was insignificant, from 40% (26 patients) to 29.2% (19 patients) (χ2=1.67; p=0.19). The results of spectral-temporal mapping indicate that a course of ozone therapy resulted in a significant decrease of the total number of local peaks in the QRS complex and the number of peaks with low-amplitude and high-frequency characteristics.