The development of a multivalent DNA vaccine for malaria

According to the latest report from the World Health Organization (December 1996), malaria is still a public health problem in more than 90 countries, inhabited by a total of some 2.4 billion people or 40% of the world’s population. Worldwide incidence of the disease is estimated to be 300–500 million clinical cases each year. Mortality due to malaria is estimated to be in the range of 1.5–2.7 million deaths annually. The vast majority of deaths occur among young children in Africa, especially in remote rural areas with poor access to health services. Immunity to malaria seems to occur among residents of malarious areas with increasing age which prevents an even greater number of deaths. However, this type of protection is short-lived and requires frequent exposure to the malaria parasite.