Characteristics of false positive findings in CT colonography CAD: a comparison of two fecal tagging regimens
2009
The successful application of Computer Aided Detection schemes to CT Colonography depends not only on their
performances in terms of sensitivity and specificity, but also on the interaction with the radiologist, and thus ultimately
on factors such as the nature of CAD prompts and the reading paradigm. Fecal tagging is emerging as a widely accepted
technique for patient preparation, and patient-friendlier schemes are being proposed in an effort to increase compliance
to screening programs; the interaction between CAD and FT regimens should likewise be taken into account. In this
scenario, an analysis of the characteristics of CAD prompts is of paramount importance in order to guide further
research, both from clinical and technical viewpoints. The CAD scheme analyzed in this paper is essentially composed
of five steps: electronic cleansing, colon surface extraction, polyp candidate segmentation, pre-filtering of residual
tagged stool and classification of the generated candidates in true polyps vs. false alarms. False positives were divided
into six categories: untagged and tagged solid stool, haustral folds, extra-colonic candidates, ileocecal valve and
cleansing artifacts. A full cathartic preparation was compared with a semi-cathartic regimen with sameday fecal tagging,
which is characterized by higher patient acceptance but also higher inhomogeneity. The distribution of false positives at
segmentation reflects the quality of preparation, as more inhomogeneous tagging results in a higher number of untagged
solid stool and cleansing artifacts.
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