Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

Brett J. Hos,Marcel Camps,Jitske van den Bulk,Elena Tondini,Thomas C. van den Ende,Dina Ruano,Kees L. M. C. Franken,George M. C. Janssen,Arnoud H. de Ru,Dmitri V. Filippov,Ramon Arens,Peter A. van Veelen,Noel F.C.C. de Miranda,Ferry Ossendorp

Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer

2019

Brett J. Hos
Marcel Camps
Jitske van den Bulk
Elena Tondini
Thomas C. van den Ende
Dina Ruano
Kees L. M. C. Franken
George M. C. Janssen
Arnoud H. de Ru
Dmitri V. Filippov
Ramon Arens
Peter A. van Veelen
Noel F.C.C. de Miranda
Ferry Ossendorp

ABSTRACTThe murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is sensitive for immune checkpoint immunotherapy. We set out to analyze endog...

Keywords:

Epitope
PD-L1
Immunotherapy
Cancer research
ENDOG
Medicine
Cancer
Colorectal cancer
Cytotoxic T cell
Immunology
Immune checkpoint
Exome sequencing
Vaccination

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