Synthesis of Polyalkoxy-3-(4-Methoxyphenyl)Coumarins with Antimitotic Activity from Plant Allylpolyalkoxybenzenes

Dmitry V. Tsyganov,Natalia B. Chernysheva,Lev K. Salamandra,L. D. Konyushkin,Olga P. Atamanenko,Marina N. Semenova,Victor V. Semenov

Synthesis of Polyalkoxy-3-(4-Methoxyphenyl)Coumarins with Antimitotic Activity from Plant Allylpolyalkoxybenzenes

2013

Dmitry V. Tsyganov
Natalia B. Chernysheva
Lev K. Salamandra
L. D. Konyushkin
Olga P. Atamanenko
Marina N. Semenova
Victor V. Semenov

Novel polyalkoxy-3-(4-methoxyphenyl)coumarins – analogues of natural antimitotic compounds – were synthesized from plant allylpolyalkoxybenzenes and tested in vivo in the phenotypic sea urchin embryo assay for antiproliferative antitubulin activity.

Keywords:

Condensation reaction
Chemistry
Organic chemistry
sea urchin embryo
In vivo
Stereochemistry

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