Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.

Mario Schiffer,Beina Teng,Changkyu Gu,Valentina A. Shchedrina,Marina V. Kasaikina,Vincent A. Pham,Nils Hanke,Song Rong,Faikah Gueler,Patricia Schroder,Irini Tossidou,Joon-Keun Park,Lynne Staggs,Hermann Haller,Sergej Erschow,Denise Hilfiker-Kleiner,Changli Wei,Chuang Chen,Nicholas J. Tardi,Samy Hakroush,Martin K. Selig,Aleksandr Vasilyev,Sandra Merscher,Jochen Reiser,Sanja Sever

Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.

2015

The small molecule Bis-T-23 targets actin polymerization to improve renal morphology and function in several mouse models of kidney injury and disease.

Keywords:

Small molecule
Dynamin
Immunology
Actin
Kidney disease
Zebrafish
Kidney Glomerulus
Kidney
Biology
Biochemistry
Diabetes mellitus
Cell biology
actin cytoskeleton

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