G9a and Glp Methylate Lysine 373 in the Tumor

The tumor suppressor p53 is regulated by numerous post-translational modifications. Lysine methylation has recentlyemergedasakeypost-translationalmodificationthatalterstheactivityofp53.Here,wedescribeanovellysinemethylationsitein p53 that is carried out by two homologous histone methyl-transferases, G9a and Glp. G9a and Glp specifically methylatep53 at Lys