Synthesis of New Pyrazoline Derivatives and Its Antimicrobial and Antioxidant Activities
2017
Resistance gained by microorganism to conventional
antimicrobial agents has lead to the development of new
antimicrobial agents against pathogenic microbes. Chalcones
and their derivatives proved to be an important molecular
scaffold for the search of new pharmaceutically active molecules. Among the various derivatives of chalcones, synthesis of pyrazolines has gained major attention due to their promising biological activities such as anticancer, antimicrobial, antidepressant, immunosuppressive, anti-inflammatory, etc.1−8 Many studies revealed that incorporation of pyrazole moiety into various heterocyclic ring systems gives worthwhile molecules from the biological point of view.9−11 Several marketed drugs such ascelecoxib12 and rimonabant13 contains pyrazole as their core molecular unit.14,15
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