Ultrasound-Guided in Vivo Delivery of Cold Plasma Gas for Cancer Therapy via Microbubbles

Cold atmospheric plasma (CAP) is expected to be a novel anti-cancer therapy strategy that has much less drug resistance or side effects. However, how to effectively deliver CAP to target lesion in vivo is still challenging. In this paper we design and prepare a kind of stable CAP/C 3 F 8 MBs for image-guided controllable delivery of CAP in vivo, and verify their feasibility for offering a long-time window for CAP-based cancer therapy. The experiment results demonstrate that, CAP/C 3 F 8 MBs cause an effective echogenic response, and the corresponding half-life of signal intensity in vivo achieves over 3 minutes.