248. Why so Much Vancomycin and Piperacillin/Tazobactam Usage Given Known Risks of Nephrotoxicity

Background Despite years of published data describing the increased risk of nephrotoxicity with use of vancomycin and piperacillin/tazobactam (VPT), this combination remains one of the most utilized antibiotic combinations at our institution. There is limited data describing the appropriateness of empiric use of this broad-spectrum regimen. Our primary objective was to evaluate the appropriateness of the anti-methicillin resistant Staphylococcus aureus (MRSA), anti-pseudomonal, and anti-anaerobic spectrum of activity for patients empirically treated with this combination. Our secondary objective was to evaluate the appropriateness of diagnostic evaluation in patients started on this combination.