YTTRIUM OXIDE: A HIGHLY EFFICIENT CATALYST FOR THE SYNTHESIS OF PYRANO[2,3-d]PYRIMIDINE DERIVATIVES IN AQUEOUS METHANOL MEDIA

Synthesis of pyrano[2,3-d]pyrimidine derivatives has been achived by one-pot three component condensation reactions of various aromatic aldehydes, malononitrile and barbituric acid in aqueous methanol using yttrium oxide (Y 2 O 3 ) as a catalyst. The potential application of Y 2 O 3 in various synthesis increasing rapidly; due to its reaction simplicity, minimum reaction time, high yields, environment friendly procedure and low cost various chemicals. The reactants are completely dissolved in aq. methanol (70%) and afford high yield of products.