AMELIORATIVE EFFECT OF ZINGERONE AGAINST LEAD INDUCED SPLEEN TOXICITY OF SWISS ALBINO MICE (MUS MUSCULUS)

Lead is a toxic heavy metal found in earth crust. Poisoning of lead is a serious global problem for a long time. The experiment was conducted to explain the preventive effect of Zingerone against lead poisoning. Toxicity of lead was assessed by applying lead acetate to healthy Swiss albino mice (Mus musculus) for 12 weeks continuously followed by administration of Zingerone along with lead by oral gavage at selected doses for 4 weeks. Morphological, biochemical and histological parameters were done to show the ill effects of lead on spleen in dose dependent manner. Application of Zingerone at a specific dose resulted in a significant reduction of the above parameters. Thus this herbal drug offers a significant ameliorating effect against lead toxicity.