Paediatric multiple sclerosis: What it is and what it is not
2019
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system of autoimmune
origin. Demyelination of the brain, optic nerves and spinal cord causes permanent mental and physical
disability. The diagnosis of MS in children, as in adults, requires evidence of dissemination of
inflammatory activity in more than one central nervous system (CNS) location (i.e., dissemination in
space (DIS)) and recurrent disease over time (i.e. dissemination in time (DIT)). When compared at
onset, those diagnosed with MS are more likely to have one or more brain lesions, positive oligoclonal
bands, have evidence of remote EBV infection and lower levels of Vitamin D as compared to children
with monophasic illness.
The identification of myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies and subsequent
discovery of their pathogenic mechanisms has led to a paradigm shift in the classification of relapsing
demyelinating syndromes. This is reflected in the 2017 revised diagnostic criteria which emphasises the
exclusion of MS mimics and aims to enable earlier diagnosis and thus treatment initiation.
The long-term efficacy of individual therapies is hard to evaluate due to small patients numbers and to
the relatively high number of patients who switch therapy. Nevertheless, an improvement in prognosis
with a globally reduced annual relapse rate is observed compared to pre-treatment era. Given the
higher relapse rate and concerning cognitive outcomes in children, there is a question whether more
rapid escalation or even using more potent agents earlier should be used in children while considering
short and long-term safety profile of these drugs. With the results of the first randomised controlled trial
of Fingolimod versus Interferon Beta-1a in paediatric MS published this year and several clinical trials
underway there is hope for further progress in the field of paediatric MS.
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