Plasma beta-carotene, retinol, and alpha-tocopherol levels in relation to glycemic control of children with insulin-dependent diabetes mellitus.

Plasma β-carotene, α-tocopherol and retinol were measured in 15 female and 5 male children with insulin-dependent diabetes mellitus (IDDM), and the correlations with plasma hemoglobin Ale (HbA 1 c) and fructosamine were analyzed. Twelve female and 8 male children served as age-matched controls. The plasma β-carotene and α-tocopherol levels of the IDDM children were significantly higher than those of the control children, but there were no differences in plasma retinol or total lipid levels. The plasma β-carotene level, β-carotene/retinol ratio and β-carotene/total lipids ratio each showed significant correlations with serum HbAlc and fructosamine in all subjects studied. Similarly, the plasma α-tocopherol level and α-tocopherol/total lipids ratio were correlated with these indexes of glycemic control. These findings suggest certain mechanisms may exist to prevent lipid peroxidation and vascular complications in IDDM patients.