Oxidative burden and antioxidant defense system in polymorphonuclear leukocytes of human lung diseases.
2002
Superoxide anion (02 .. ) and hydrogen peroxide (H20 2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.00 1). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.00l). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14C02 from [1_'4C]_ glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and non malignant lung diseases, the changes being more in the malignancy are indicated. Polymorphonuclear neutrophils (PMNs) play an important role as a mediator of tissue destructive events in inflammatory diseases, ranging from rheumatoid arthritis and myocardial reperfusion injury to respiratory distress syndrome l
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