A pilot randomised controlled trial examining the feasibility, acceptability and impact of giving information on personalised genomic risk of melanoma to the public, for motivating preventive behaviours.

1556Background: Melanoma is highly preventable. We aimed to evaluate the feasibility and acceptability of giving information on personalised genomic risk of melanoma to the public, and its impact on behaviours, psychosocial and ethical issues. Methods: We recruited 120 people (22-69 years); consent was 41% overall but differed by age and sex. Participants were randomised to the intervention (personal genomic risk of melanoma based on variants in 21 genes, with a personalised booklet and telephone-based genetic counselling; plus educational materials) or the waitlist control (educational materials only). Follow-up was conducted after 3-months. Results: 118 (98%) completed baseline data and were randomised (intervention=60; control=58). Follow-up questionnaires were completed by 108 (92%) participants and 4-day objective UV measures by 101 (86%). Intervention participants reported high satisfaction with the risk booklet (mean 8.6, SD 1.6) and genetic counselling (mean 8.1, SD 2.2) on a 0-10 scale. Prelimina...