Protective effects of paeoniflorin on cultured cortical neurons of mice

Culturing cortical neurons with PF at 20.8 and 41.6 mg·L~(-1) for 4d increase the survival of neurons and decreased the death rate of cells. Damaged neurons induced by cultured with KA (50 #mu#mol·L~(-1)) for 30 min showed various changes, such as cell swelling, lacking of dioptre, nucleus shifting to the cell periphery, and higher mortality. While pretreated with PF 20.8 and 41.6 mg·L~(-1) for 4d, the cortical neurons were resistant to the injury of KA. PF can increase the mouse cortical neuronal survival rate, decrease the mortality and protect neurons against KA induced neurotoxicity.