Preclinical Evaluation of the Short-Term Toxicity of 4-(N)-Docosahexaenoyl 2´, 2´- Difluorodeoxycytidine (DHA-dFdC)

Solange A. Valdes,Youssef W. Naguib,Rick Avery Finch,Wallace B. Baze,Christopher A. Jolly,Zhengrong Cui

Preclinical Evaluation of the Short-Term Toxicity of 4-(N)-Docosahexaenoyl 2´, 2´- Difluorodeoxycytidine (DHA-dFdC)

2017

Solange A. Valdes
Youssef W. Naguib
Rick Avery Finch
Wallace B. Baze
Christopher A. Jolly
Zhengrong Cui

Purpose This study was designed to test the short-term toxicity of DHA-dFdC in a mouse model and its efficacy in a mouse model of leukemia at or below its repeat-dose maximum tolerated dose (RD-MTD).

Keywords:

Leukemia
Toxicity
Maximum tolerated dose
Pharmacology
Gemcitabine
Chemistry
Pharmacy
short term toxicity
pharmacology toxicology

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