Shorter or standard chemoradiotherapy in elderly glioblastomamultiforme (GBM) patients.

e13003 Background: The optimal treatment in elderly GBM patients is still debated. Previous studies with shorter RT course (40Gy/15F.) have shown no statistically significant difference in OS compared to standard treatment (60Gy/30F). Nowadays the role of combined RT and Temozolomide (TMZ) is being investigated in a large ongoing study (NCIC-CTG CE.6/EORTC 26062). Methods: In this study we retrospectively evaluated the outcome of elderly (> 65 years) glioblastoma patients consecutively treated in our Center between 2005 and 2012 with RT (40 Gy/15 F.) plus concomitant and adjuvant TMZ (“short Stupp”) Group 1, or with RT ( 60 Gy/30 F) plus concomitant and adjuvant TMZ (Classical Stupp’s Protocol) Group 2. Median age of the 18 pts was 71y (range 65-78), with KPS >50% in 14/18 (77.7%) and < 50% in 3/18 (16%), (1 not recorded). Nine pts were males and 9 females. Eight out of 18 pts (44%) had received radical surgery, 6 (33%) subtotal, and for 4 (22%) only biopsy. All patients were treated with post-operative r...