PALLADIUM-CATALYZED SYNTHESIS OF 3-(ALKYLAMINO)ISOINDOLIN-1-ONES BY CARBONYLATIVE CYCLIZATION OF 2-BROMOBENZALDEHYDE WITH PRIMARY AMINES

2-Bromobenzaldehyde reacts with an excess of primary amines under a carbon monoxide in the presence of a catalytic amount of bis(triphenylphosphine)palladium(II) chloride together with triethylamine to give the corresponding 3-(alkylamino)isoindolin-1-ones in good yields.