Molecular features of adenylyl cyclase isoforms and cAMP signaling: A link between adenylyl cyclase 7 and depression

2021 
Abstract Adenylyl cyclases (ACs) are proteins that catalyze the reaction producing cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). There are 10 isoforms of ACs expressed in humans, 9 of which are membrane-bound proteins. The actions of clinically used antidepressants are thought to modulate AC activity indirectly. Accordingly, activation of the cAMP signaling pathway has been correlated with antidepressant effects. Adenylyl cyclase 7 (AC7) is an AC isoform of interest particularly for the suggested link between its overactivity and the onset of depressive disorders. Though the downstream effects of ACs are being researched and studied, directly targeting these proteins for therapeutic purposes is still a challenge and most AC isoforms, including AC7, do not have selective inhibitors. In this chapter, we will review the biochemistry of ACs and discuss the evidence linking cAMP signaling with depressive disorders with a focus on AC7.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    64
    References
    0
    Citations
    NaN
    KQI
    []