Stereoselective synthesis of the C1-C13 fragment of 2,3-dihydrodorrigocin A.

The first synthesis of the C1−C13 fragment of 2,3-dihydrodorrigocin A has been achieved from 6-bromohexanoic acid in 14 linear steps and an overall yield of 2%. The configurations of the stereogenic centers C8, C9, and C10 have been determined to be the same as for migrastatin.