Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

Charles-Gabin Mabiala-Bassiloua,Magdalena Zwolinska,Helene Therisod,Jurgen Sygusch,Michel Therisod

Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases

2008

Charles-Gabin Mabiala-Bassiloua
Magdalena Zwolinska
Helene Therisod
Jurgen Sygusch
Michel Therisod

We report the first unambiguous syntheses of glucitol-1,6-bis-phosphate and mannitol-1,6-bis-phosphate and their competitive inhibition of various fructose bis-phosphate aldolases.

Keywords:

Enzyme
Chemical synthesis
Organic chemistry
Aldolase A
Mannitol
Fructose
Non-competitive inhibition
Fructose-bisphosphate aldolase
Biochemistry
Chemistry
Phosphate
antibacterial agent

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